Medical Approach

There are similarities between the overtraining syndrome and major depression. The relationship between the two as well as evidence from certain case studies support the potential for using antidepressants to treat OTS.

Autonomic balance and the Sympathetic-Adrenal Medullary Axis (SAM)

• Regulated by norepinephrine/epinephrine

Cortisol and the Hypothalamic-Pituitary-Adrenocortical Axis (HPA)

• Regulated by serotonin

Use of antidepressants to restore neurotransmitter imbalance

• selective serotonin reuptake inhibitors
  fluoxetine, fluvoxamine, paroxetine, sertraline

• norepinephrine reuptake inhibitors
  viloxazine, reboxetine

• serotonin and norepinephrine reuptake inhibitors
  venlafaxine, mirtazapine, milnacipran

See table VII. from the Unknown Mechanism of the Overtraining Syndrome

References: [1]